Join us on our journey to end blood cancer.
We are the only foundation in the world that supports patients with RUNX1-FPD.
Join us on our journey to
end blood cancer.
We are the only foundation in the world that supports patients with RUNX1-FPD.
What is RUNX1 Familial Platelet Disorder (RUNX1-FPD)?
RUNX1 Familial Platelet Disorder (RUNX1-FPD) is a genetic condition caused by a variant (mutation) in the RUNX1 gene. Individuals with RUNX1-FPD are born with a RUNX1 variant in every cell of the body.
Most people have two healthy copies of the RUNX1 gene, but people with RUNX1-FPD have only one healthy copy. The second copy doesn’t work properly because of a variant, which causes low platelets and/or platelets that don’t function well.
RUNX1-FPD can increase the chance of having blood cancer. Some individuals never develop blood cancer, while others may develop one. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are the two most common types of blood cancers.
People with RUNX1-FPD may also tend to have heavy bleeding with injury, many bruises, frequent nosebleeds, bleeding gums, heavy periods for girls and women, and more bleeding during surgery.
New to RUNX1-FPD?
Whether you’ve recently received a diagnosis or learned that RUNX1-FPD runs in your family, find information about medical care, everyday life, and support.
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